Table 1.

Sensitivity of T-ALL cell lines to GSI

Cell lineNOTCH1 statusNICD *GI50 (μmol/L)
T-ALL-1Wild-type00.11
KOPTK1Mutated30.15
DND41Mutated20.25
HPB-ALLMutated30.38
RPMI8402Mutated30.86
CEMMutated23.2
PF382Mutated33.2
HSB2Wild-type13.7
BE-13Mutated36.8
SUP-T11Wild-type07.1
JURKATWild-type3>10
LOUCYWild-type0>10
MOLT-4Mutated3>10
MOLT-16Wild-type0>10
SKW-3Mutated1>10
  • * NICD levels are reported qualitatively based on Western blot signal: 0, none; 1, low; 2, medium; 3, high.

  • GI50s are based on growth inhibition as measured by a 7-d ATP-based viability assay.