Table 1.

Phenotype and cytokine profile of CD4+Foxp3+ T cells in cancer and ulcerative colitis patients

Ulcerative colitisTumors
TotalColon cancerHepatic cancerMelanomaOvarian carcinomaPancreatic carcinomaRenal cell carcinoma
n74348121729
IL-28 ± 58 ± 25 ± 36 ± 13 ± 14 ± 48 ± 99 ± 3
IL-102 ± 13 ± 12 ± 10.2 ± 13 ± 12 ± 11 ± 05 ± 5
IFN-γ9 ± 56 ± 26 ± 25 ± 45 ± 45 ± 18 ± 46 ± 2
Granzyme B2 ± 14 ± 22 ± 16 ± 13 ± 15 ± 22 ± 15 ± 2
Ki-674 ± 26 ± 15 ± 13 ± 15 ± 15 ± 17 ± 17 ± 2
PD-110 ± 713 ± 65 ± 12 ± 31 ± 219 ± 88 ± 39 ± 6
  • NOTE: Single-cell suspensions were prepared from fresh cancer and colitic tissues. Cells were stained with relevant antibodies. T-cell subsets were analyzed by FACS. Results are expressed as the percent ± SE of targeted proteins in CD4+FOXP3+ T cells.