Table 1.

In vivo tumor formation ability of Wt, p53−/−, Rb−/−, or p53−/−Rb−/− MSCs inoculated in immunodeficient mice

MSC genotypeTumor incidenceDays to tumor developmentHistologic analysis
Wt0/8*NT
p53−/−4/8*43–123 (74)Leiomyosarcoma
Rb−/−0/8*NT
p53−/−Rb−/−4/8*43–69 (52)Leiomyosarcoma
  • *Mice without tumors were sacrificed after 150 days.

  • NT, no tumor was detected.

  • Range of days for tumor development (median).

  • *Mice without tumors were sacrificed after 150 days.

  • NT, no tumor was detected.

  • Range of days for tumor development (median).