Table 1.

Missense mutations of PI3K isoforms, PTEN, KRAS, and BRAF in JFCR39

IDOriginCell linePIK3CAPIK3CBPIK3CDPIK3CGPTENKRASBRAF
01Lung ca.NCI-H23P538LG12C
02NCI-H226S442Y (SNP)
03NCI-H522
04NCI-H460E545K (genomic)Q61H
05A549G12S
06DMS273M259IK128N
07DMS114
11Colorectal ca.HCC2998I391M (SNP)R149QT857AY46CA146T
R562QR273HR130Q
L466MF341V
12KM-12G129*
K267fs(del.-1)*9
13HT-29P449TS442Y(SNP)V600E
15HCT-15E545KR628QS174LG13D
D549N
16HCT-116H1047REx.16 del.G13D
21Gastric ca.St-4S442Y(SNP)E291*G12A
22MKN1E545K
23MKN7T456A (SNP)A621S
24MKN28T456A (SNP)A621S
25MKN45
26MKN74T456A (SNP)A621S
31Breast ca.HBC-4E1051KS442Y(SNP)
32BSY-1H1047REx.1-9 del.
34HBC-5
35MCF-7E545KS442Y(SNP)
36MDA-MB-231G13DG464V
41Ovarian ca.OVCAR-3
42OVCAR-4
43OVCAR-5G12V
44OVCAR-8N522S
45SK-OV-3H1047R
51Brain ca.U251E242fs(ins.+2)*15
52SF-268
53SF-295S312CR233*
54SF-539Ex.1-9 del.
55SNB-75
56SNB-78L719FT26fs(SD del.)
61Renal ca.RXF-631LS442Y(SNP)
62ACHN
71MelanomaLOX-IMVIV600E
91Prostate ca.DU-145A686TS442Y(SNP)
92PC-3S312CS442Y(SNP)Ex.3-9 del.
Total # (without SNP)10 (9)47 (4)15 (7)1093

NOTE: Underline indicates a homozygous mutation.