Table 1.

Final average papilloma volume and number per mouse at 21 wk

Treatment groupNAverage volume/mouse (mm3)SEAverage number/mouseSE
DMBA/WT-acetone170.000.000.0000.0
DMBA/KO-acetone160.000.000.0000.0
DMBA/WT-10 μmol capsaicin170.000.000.0000.0
DMBA/KO-10 μmol capsaicin170.000.000.0000.0
TRPV1/WT-TPA treated162.231.360.310.18
TRPV1/KO-TPA treated1612.06*4.471.75*0.37
TRPV1/WT 10 μmol capsaicin/TPA1624.375.417.941.27
TRPV1/KO 10 μmol capsaicin/TPA1755.80*10.5913.18*1.67
  • *Significantly greater average volume and number of papillomas in TRPV1/KO mice compared with TRPV1/WT mice (P < 0.05).

  • Significantly greater average volume and number of papillomas in capsaicin-treated TRPV1/WT or TRPV1/KO mice compared with untreated TRPV1/WT or TRPV1/KO mice.