Table 2.

Tumor spectra in Mdm4 transgenic mice

Tumor typesMdm4Tg1 (n = 24)p53+/− (n = 44)Mdm4Tg1p53+/− (n = 44)Mdm4Tg15 (n = 13)
Sarcoma9 (37%)30 (68%)28 (64%)4 (31%)
    Hemangiosarcoma4310
    Osteosarcoma1*15180
    Sarcoma, NOS41273
    Malignant peripheral0011
    Nerve sheath tumor
    Neurofibrosarcoma1
Carcinoma3 (13%)2 (5%)5 (11%)1 (7%)
    Adenocarcinoma2140
    Spindle cell carcinoma0100
    Squamous cell carcinoma1010
    Hepatocellular carcinoma0001
Lymphoma8 (33%)10 (23%)5 (11%)4 (31%)
Histiocytic sarcoma§4 (17%)2 (5%)6 (14%)4 (31%)
  • *This osteosarcoma had metastasis.

  • Not otherwise specified.

  • One of three sarcomas NOS had metastasis.

  • §Macrophage origin.

  • Two of four histiocytic Sarcomas had metastasis.