Table 1.

Resistance characterization of the Rh41-807R and Rh41-MAB391R models to multiple IGF-IR inhibitors

InhibitorsIC50 (nmol/L)
Rh41Rh41-807RRh41-MAB391R
BMS-754807581127
MAB3910.1>2,000>2,000
BMS-53692431>1,00090
BMS-8309130.0290.02
BMS-8098002551.29
BMS-808931<128<0.64

NOTE: The sensitivity/resistance is defined as IC50, which is the drug concentration that produced a 50% growth inhibition compared with untreated controls in [3H]thymidine incorporation assays.