Table 1.

Lymphocyte infiltrates in MCA tumors of Treg-depleted mice

GroupCD8+ (%)CD4+ (%)Treg, Foxp3 (%)B, CD19 (%)NK (%)CD8+:B
PBS (n = 10)21.7 ± 3.315.2 ± 2.45.6 ± 0.87.6 ± 1.411.1 ± 1.63.8 ± 0.7
DT-NR (n = 13)38.4 ± 4.017.0 ± 1.70.9 ± 0.26.6 ± 2.26.7 ± 1.115.6 ± 4.5
DT-R (n = 6)45.2 ± 7.816.5 ± 2.90.4 ± 0.13.8 ± 1.95.1 ± 0.632.9 ± 12.5

NOTE: A group of 35 DEREG mice bearing established MCA tumors (>50 mm2) was treated with either PBS or 1,000 ng DT. Tumors in the DT-treated group were classified as nonresponders or responders (if they showed two consecutive decreases in tumor size). Tumors from PBS-treated (n = 10) or DT-treated nonresponder (n = 13) or responder (n = 6) mice were harvested at the second measurement, and single-cell suspensions were generated for FACS analysis. Percentage within the live (7-AAD) CD45+CD11b population ± SE.

Abbreviations: NR, nonresponders; R, responders.