Table 2.

Pharmacokinetic parameters of resveratrol and its three major metabolites in the plasma of healthy volunteers who received daily oral resveratrol for between 21 and 28 d (n = 10 per dose level)

Parameter
Cmax (ng/mL)*,Cav (ng/mL)*,Tmax (h)T1/2 (h)AUClast (ng × h/mL)
Resveratrol, dose (g)
    0.543.8 (89.4) [0.19]9.93 (69.7) [0.04]1.00 (0.25–5.0)4.77 (62.1)175 (83.7)
    1.0141 (68.9) [0.62]22.8 (68.4) [0.10]1.00 (0.25–1.82)9.70 (37.5)503 (79.3)
    2.5331 (59.2) [1.45]48.1 (46.5) [0.21]1.00 (0.23–4.97)9.17 (42.0)1,250 (40.0)
    5.0967 (53.5) [4.24]126 (55.8) [0.55]1.08 (0.5–1.5)7.85 (25.1)4,097 (107)
Resveratrol-4′-O-glucuronide, dose (g)
    0.5186 (56.7) [0.82]50.2 (51.1) [0.22]1.27 (1.0–5.0)3.78 (42.2)1,331 (56.4)
    1.0710 (57.9) [3.12]178 (64.8) [0.78]1.50 (0.83–5.0)5.77 (44.6)3,774 (53.2)
    2.51,137 (88.0) [4.99]323 (66.9) [1.42]1.50 (0.25–5.0)8.14 (38.6)7,245 (54.4)
    5.02,323 (45.5) [10.2]667 (61.3) [2.93]1.50 (1.0–5.0)7.55 (21.2)19,984 (59.0)
Resveratrol-3-O-glucuronide, dose (g)
    0.5184 (86.3) [0.81]37.7 (56.2) [0.17]1.27 (1.0–5.0)4.98 (41.6)875 (51.4)
    1.0588 (48.4) [2.45]94.4 (28.9) [0.42]1.50 (0.83–5.0)5.50 (24.5)2,087 (37.7)
    2.51,546 (107) [6.78]204 (64.0) [0.89]1.42 (1.0–1.5)6.43 (40.8)5,300 (47.1)
    5.03,886 (48.6) [17.1]649 (34.8) [2.85]1.50 (0.5–1.6)5.19 (52.7)22,084 (93.9)
Resveratrol-3-O-sulfate, dose (g)
    0.5563 (35.1) [2.47]118 (26.9) [0.52]1.04 (1.0–5.0)3.09 (15.3)3,558 (51.6)
    1.01,694 (35.2) [7.43]377 (48.7) [1.65]1.50 (0.83–5.0)7.37 (51.4)9,464 (42.3)
    2.52,292 (50.7) [10.1]604 (43.8) [2.65]1.33 (1.0–1.5)6.84 (40.6)15,638 (39.0)
    5.04,172 (40.3) [18.3]1,384 (42.3) [6.07]1.25 (0.25–5.0)7.98 (29.6)38,900 (49.5)

Abbreviations: Cmax, maximal plasma concentration; Cav, average plasma concentration; Tmax, time of maximal plasma concentration (Cmax); T1/2, apparent first-order elimination half-life; AUClast, area under the plasma concentration versus time curve from time 0 to the last sampling blood draw collected.

  • *Mean value in ng/mL.

  • CV% (round brackets), mean value in nmol/mL [square brackets].

  • Median (range).