Table 4.

Per allele regression estimate, with 95% confidence intervals and associated P values from cross-sectional, within-sibship, between-sibship, and combined analyses for each variant and each adjusted mammographic density measure

VariantCross-sectional (95% CI)PxWithin sibships (95% CI)PwBetween sibships (95% CI)PbCombined (95% CI)Pc
Dense area*
    rs29815820.02 (−0.11–0.14)0.80.18 (0.00–0.36)0.06−0.13 (−0.3–0.02)0.090.00 (−0.12–0.12)1.0
    rs8893120.11 (−0.03–0.24)0.10.17 (−0.06–0.39)0.10.12 (0.04–0.29)0.10.14 (0.01–0.27)0.04
    rs12443621−0.02 (−0.14–0.10)0.70.07 (−0.12–0.26)0.5−0.10 (−0.25–0.05)0.2−0.03 (−0.15–0.09)0.6
    rs2107425−0.14 (−0.27–0.01)0.03−0.02 (−0.23–0.20)0.9−0.12 (−0.30–0.05)0.2−0.08 (−0.21–0.05)0.2
    rs38171980.24 (0.11–0.37)0.00020.23 (0.03–0.42)0.020.19 (0.03–0.35)0.020.21 (0.08–0.33)0.001
    rs8051542−0.05 (−0.17–0.07)0.4−0.04 (−0.22–0.15)0.70.02 (−0.13–0.17)0.80.00 (−0.12–0.11)0.9
    rs132816150.12 (0.00–0.24)0.050.36 (0.16–0.56)0.00050.15 (−0.007–0.3)0.060.22 (0.10–0.35)0.0003
    rs17468277−0.18 (−0.34–0.01)0.040.01 (−0.27–0.28)0.96−0.19 (−0.40–0.01)0.07−0.12 (−0.29–0.04)0.2
    rs133870420.00 (−0.12–0.11)0.90.12 (−0.05–0.30)0.2−0.05 (−0.20–0.1)0.50.03 (−0.09–0.14)0.7
    rs981782−0.11 (−0.24–0.01)0.06−0.11 (−0.30–0.09)0.3−0.08 (−0.23–0.07)0.3−0.09 (−0.21–0.03)0.1
    rs49737680.02 (−0.10–0.14)0.7−0.04 (−0.24–0.15)0.70.09 (−0.06–0.23)0.20.04 (−0.08–0.16)0.5
    rs65049500.02 (−0.11–0.15)0.80.10 (−0.11–0.31)0.30.07 (−0.09–0.22)0.40.08 (−0.05–0.21)0.2
    Pu0.00100.0070.0080.0005
Percent dense area
    rs29815820.12 (−0.82–1.05)0.80.34 (−1.10–1.78)0.6−0.69 (−1.9–0.55)0.3−0.25 (−1.19–0.69)0.6
    rs8893120.82 (−0.20–1.84)0.11.71 (−0.04–3.46)0.060.89 (−0.4–2.18)0.21.18 (0.14–2.22)0.03
    rs12443621−0.05 (−0.98–0.87)0.90.19 (−1.30–1.68)0.8−0.30 (1.5–0.90)0.6−0.11 (−1.04–0.82)0.8
    rs2107425−0.71 (−1.71–0.3)0.20.40 (−1.28–2.08)0.6−0.37 (−1.67–0.93)0.6−0.08 (−1.11–0.94)0.9
    rs38171980.98 (0.00–1.95)0.051.75 (0.23–3.28)0.030.41 (−0.87–1.70)0.50.97 (−0.01–1.95)0.05
    rs8051542−0.04 (−0.95–0.87)0.90.22 (−1.25–1.68)0.80.54 (−0.65–1.73)0.40.41 (−0.51–1.34)0.4
    rs132816151.02 (0.09–1.96)0.032.57 (1.01–4.13)0.0011.67 (0.47–2.87)0.0062.01 (1.06–2.96)0.00004
    rs17468277−0.89 (−0.20–0.21)0.11.59 (−0.58–3.76)0.2−1.28 (−2.88–0.33)0.1−0.26 (−1.55–1.03)0.7
    rs133870420.05 (−0.83–0.94)0.90.74 (−0.61–2.1)0.3−0.16 (−1.36–1.04)0.80.24 (−0.66–1.14)0.6
    rs981782−0.40 (−1.33–0.53)0.4−0.27 (−1.76–1.23)0.70.000 (−1.20–1.20)1.0−0.11 (−1.04–0.83)0.8
    rs49737680.01 (−0.91–0.93)1.00.25 (−1.29–1.78)0.80.30 (−0.86–1.46)0.60.28 (−0.65–1.21)0.6
    rs65049500.05 (−0.93–1.02)0.92.35 (0.74–3.96)0.005−0.29 (−1.53–0.95)0.60.69 (−0.29–1.67)0.2
    Pu0.20.0040.250.007
Nondense area
    rs2981582−0.05 (−0.19–0.10)0.50.02 (−0.17–0.21)0.80.00 (−0.18–0.17)1.00.01 (−0.12–0.13)0.9
    rs889312−0.12 (−0.28–0.04)0.1−0.24 (−0.48–0.01)0.04−0.09 (−0.27–0.09)0.3−0.15 (−0.29–0.01)0.04
    rs12443621−0.01 (−0.15–0.13)0.90.25 (0.05–0.45)0.01−0.08 (−0.24–0.09)0.40.06 (−0.07–0.18)0.4
    rs21074250.08 (−0.07–0.23)0.30.01 (−0.21–0.23)0.9−0.04 (−0.22–0.14)0.4−0.02 (−0.16–0.12)0.8
    rs38171980.10 (−0.05–0.25)0.2−0.17 (−0.38–0.03)0.090.18 (0.00–0.36)0.040.03 (−0.11–0.16)0.7
    rs8051542−0.02 (−0.16–0.12)0.80.04 (−0.15–0.24)0.7−0.05 (−0.21–0.12)0.6−0.01 (−0.14–0.12)0.9
    rs13281615−0.02 (−0.16–0.12)0.8−0.07 (−0.28–0.13)0.5−0.07 (−0.24–0.10)0.4−0.07 (−0.2–0.06)0.3
    rs174682770.08 (−0.11–0.28)0.4−0.25 (−0.54–0.04)0.090.07 (−0.15–0.29)0.5−0.05 (−0.23–0.13)0.6
    rs13387042−0.03 (−0.16–0.11)0.7−0.12 (−0.3–0.06)0.2−0.03 (−0.20–0.13)0.7−0.07 (0.20, 0.05)0.2
    rs981782−0.04 (−0.19–0.1)0.60.14 (−0.05–0.34)0.2−0.05 (−0.22–0.11)0.50.03 (−0.10, 0.16)0.7
    rs49737680.06 (−0.08–0.20)0.4−0.04 (−0.24–0.17)0.70.01 (−0.15–0.17)0.9−0.010 (−0.13–0.12)0.9
    rs6504950−0.05 (−0.20–0.10)0.5−0.46 (−0.67–0.24)<0.00010.20 (0.03–0.37)0.02−0.06 (−0.19–0.08)0.4
    Pu0.80.00050.30.7

NOTE: Pu is significance of P values against the uniform distribution.

  • *Square-root transformed and adjusted for age, difference of time between mammogram and interview, menopausal status, number of live birth, BMI, number of years drinking alcohol, number of years using hormone replacement therapy, number of years using oral contraceptives and begin breast dysplasia removed.

  • Untransformed and adjusted for as in the dense area, plus number of years smoking.

  • Square-root transformed and adjusted for age, menopausal status, number of live birth, BMI, number of years drinking alcohol, number of years on hormone replacement therapy and number of years smoking.