Table 1.

Haplotypes in the CLOCK gene and breast cancer risk

Common or variant allele*Frequency (%)Controls, nCases, nOR (95% CI)ER/PR+ER/PR−
Cases, nOR (95% CI)Cases, nOR (95% CI)
CVCCVCCCC33.483212860.95 (0.78–1.16)540.94 (0.66–1.36)440.68 (0.46–0.99)
VCCCCVVCV23.652162151.18 (0.95–1.48)381.13 (0.75–1.70)481.54 (1.04–2.27)
CCVVCCCVC18.471911430.78 (061–1.00)290.79 (0.51–1.24)310.88 (0.57–1.36)
CCVVCVCVC12.741201100.97 (0.73–1.28)221.02 (0.62–1.70)251.17 (0.72–1.91)
CCVCCCCVC4.2740350.98 (0.61–1.57)50.78 (0.29–2.07)50.87 (0.32–2.32)
VVCCCVVCV3.5624381.87 (1.10–3.18)112.25 (1.04–4.87)61.33 (0.52–3.43)
Protective allele36.493632930.81 (0.66–0.98)580.82 (0.57–1.17)610.91 (0.63–1.29)
One or more risk alleles42.813863891.23 (1.01–1.48)761.27 (0.90–1.79)851.51 (1.07–2.14)
Two or more risk alleles28.432652501.31 (1.06–1.61)511.32 (0.90–1.92)571.59 (1.10–2.30)
Three risk alleles28.112492601.28 (1.04–1.58)491.26 (0.86–1.84)571.60 (1.11–2.32)
  • *SNP order: rs7698022, rs6850524, rs11133391, rs11133389, rs13102385, rs11932595, rs1801260, rs3749474, rs1048004.

  • Adjusted for age, race, family history of breast cancer, study site, menopausal status, age at menarche, and parity.