Table 1.

Functional annotation of 5′-end methylated genes in tumor samples

GO IDGO termCountPBenjaminiGenes
GO:0048513Organ development347.50E-091.33E-05IL12B, PDGFA, LECT1, BMP4, OTX2, MYF6, CNTN4, PAX9, FYN, SHOX2, EN1, CHAT, GSX2, KRT19, SIX6, POU4F3, RAX, FOXD3, GDNF, HOXD12, NPR3, HOXD3, HOXD10, MEST, ONECUT2, ALX1, NKX2-6, ONECUT1, OTP, GHSR, LAMC2, DLX2, PAX6, NKX6-1, CFTR
GO:0007420Brain development111.31E-061.16E-03CNTN4, ALX1, RAX, OTP, FYN, EN1, DLX2, BMP4, GSX2, OTX2, CFTR
GO:0007399Nervous system development223.38E-061.99E-03POU4F3, RAX, NCAM2, GDNF, BMP4, OTX2, NEFM, PCDHAC1, CNTN4, ALX1, OTP, FYN, GHSR, EN1, SHOX2, DLX2, CHAT, NKX6-1, GSX2, CRMP1, PAX6, NKX2-8, CFTR
GO:0031323Regulation of cellular metabolic process478.01E-063.54E-03ZNF560, ZNF233, EVX2, IL12B, PDGFA, BMP4, VSX2, OTX2, KLF11, MYF6, IRX5, PAX9, GSC, KLF16, EN1, SHOX2, GSX2, GRHL2, SOX7, SIX6, NKX2-8, CPEB1, TOX2, POU4F3, RAX, FOXD3, BCL6B, HOXD12, HOXD3, HOXD10, ZNF236, ONECUT2, ALX1, C14orf39, EVX1, HOXA1, ONECUT1, NKX2-6, OLIG3, OTP, PRDM14, GHSR, DLX2, NKX6-1, HOXA10, WT1, HOXA7
GO:0022008Neurogenesis131.49E-051.28E-02POU4F3, GDNF, OTX2, NEFM, CNTN4, OTP, FYN, EN1, CHAT, GSX2, PAX6, NKX6-1, NKX2-8, CFTR
GO:0048699Generation of neurons124.40E-051.29E-02CNTN4, POU4F3, OTP, GDNF, FYN, EN1, CHAT, GSX2, OTX2, NEFM, NKX2-8, PAX6, CFTR
GO:0045449Regulation of transcription424.73E-051.19E-02ZNF560, ZNF233, EVX2, VSX2, OTX2, KLF11, MYF6, IRX5, PAX9, GSC, KLF16, EN1, SHOX2, GSX2, GRHL2, SOX7, NKX2-8, SIX6, TOX2, POU4F3, RAX, FOXD3, BCL6B, HOXD12, HOXD3, HOXD10, ZNF236, ONECUT2, ALX1, C14orf39, EVX1, HOXA1, ONECUT1, NKX2-6, OLIG3, OTP, PRDM14, DLX2, PAX6, NKX6-1, HOXA10, WT1, HOXA7