Table 1.

Evaluation of predictor gene signatures

ClassLindgren/Lindgren* AUCLindgren/Sanchez AUCLindgren/Stransky AUC
SVM-based gene signature predictions§
    MS0.95 (160)0.910.91
    Grade0.95 (160)0.890.80
    Stage0.82 (115)0.980.84
    DSS0.78 (50)0.66na
    Progress0.67 (40)nana
ROC-based gene signature predictions
    MS0.990.840.91
    Grade0.930.790.86
    Stage0.900.910.89
    DSS0.750.60na
    Progress0.64nana

Abbreviations: MS, molecular subtype; na, not applicable.

  • *Gene predictors and predictions made in the present data set with cross validation.

  • Gene predictors made in the Lindgren data set and predictions made in the Sanchez-Carbayo data set.

  • Gene predictors made in the Lindgren data set and predictions made in the Stransky data set.

  • §Genes in the respective gene signatures are reported in Supplementary Table S3.The number of genes in the predictor signatures is in parentheses except for the Lindgren/Sanchez and the Lindgren/Stransky analyses in which all signatures contained 150 genes.

  • Genes in the respective gene signatures are reported in Supplementary Table S4. All gene signatures contained 100 genes.