Table 1.

PI-103 levels in plasma, intracranial, and subcutaneous tumors

TreatmentTotal PI-103 concentration, ng/mLRelative ratios
BrainSubQPlasmaBrain/plasmaSubQ/plasma
VehicleBQLBQLBQL
PI-103a25.629.92.69.911.5
PI-103b16.9249.81.72.5

NOTE: Pharmacokinetic detection of PI-103 levels by LC-MS/MS using multiple reaction monitoring in plasma, intracranial tumor, and subcutaneous tumor tissue collected from mice dosed with 25 mg/kg of PI-103 i.p.

Abbreviation: BQL, below quantization limit of 1 ng/mL.

  • aRepeated daily dose of 25 mg/kg PI-103 i.p. (collection at 2 hours after last administration).

  • bSingle dose of 25 mg/kg PI-103 i.p. (collection at 2 hours after administration).