Table 1.

In vitro kinase inhibition profile E-3810

KinaseE-3810
IC50 (nM)
VEGFR family
 VEGFR-17
 VEGFR-225
 VEGFR-310
FGFR family
 FGFR-117.5
 FGFR-282.5
 FGFR-3237.5
 FGFR-4>1000
PDGFR family
 c-Kit456
 PDGFR α175
 PDGFR β525
CSF-1R5

NOTE: Assays were done with ATP concentrations at the respective Km. IC50s; >1000 means that half-maximum inhibition was not achieved at the highest concentration tested.