Table 2.

Daily oral treatment with E-3810 inhibits the growth of different human tumor xenografts

XenograftTumor typeInitial tumor volume (mg)Dose (mg/kg/d)%TGI (d)TC (d)
HT-29Colon100-1502092 (38)27.4*/28**
4092 (38)29*/30**
A2780Ovarian100-1501581 (20)16*
3082(20)20*
A498Renal100-1501084 (43)21*
2091(40)-93 (40)27*
350-4002082 (29)35*/29**
SN12KIRenal100-1502081 (74)29**
RXF393Renal100-1502094 (20)23*/28**

NOTE: E-3810 was given p.o. at the indicated doses for 30 consecutive days, starting when tumor masses reached 100 to 150 mg or 350 to 400 mg as indicated in the text. %TGI, tumor growth inhibition; TC (d), difference between treated and control mice in time to reach 500 mg (*) or 1,000 mg (**).