Table 1.

Many different drugs can synergize with TRAIL

DrugType of drugDosesCISynergy
BortezomibProteasome inhibitor10.049+++
20.123+++
MG132Proteasome inhibitor10.313++
20.299+++
DoxorubicinTopoisomerase inhibitor10.087+++
20.092+++
5-FUInhibitor of thymidine synthesis10.463++
20.366++
EtoposideTopoisomerase II inhibitor10.065+++
20.068+++
OxamflatinHDAC inhibitor10.195+++
20.287+++
SorafenibSelective kinase inhibitor10.795+
20.316++
AzacitidineDNA/RNA methyltransferase inhibitor10.324++
20.189+++
SorbitolHyperosmotic agent10.089+++
20.002+++
StaurosporineGeneral kinase inhibitor10.307++
20.175+++

NOTE. Drugs were combined with TRAIL in different dose combinations (see Materials and Methods) and synergy determined using the Calcusyn program. All drugs displayed synergy; however, some drugs were significantly more synergistic than others.