Table 2.

Association between the EGFR mutations and the number of risk alleles combining the genotypes

Combination of polymorphismsNumber of risk allelesAll WTAll MTOR (95% CI)PEx19 del−Ex19 del+OR (95% CI)P858 L>R−858 L>R+OR (95% CI)P
−216G/T + intron 1 (CA)n083291.00 (referent)98141.00 (referent)98141.00 (referent)-
113102.20 (0.87–5.56)0.131851.94 (0.62–6.07)0.321941.47 (0.44–4.97)0.51
21514.30 (1.60–127.10)0.0082414.00 (2.34–83.67)0.005511.40 (0.15–12.88)0.57
−216G/T+Intron 1 (CA)n+R497K02591.00 (referent)3131.00 (referent)2951.00 (referent)-
146160.97 (0.37–2.50)15481.53 (0.38–6.20)0.745480.86 (0.26–2.87)1.00
220131.81 (0.64–5.08)0.312672.78 (0.65–11.86)0.192761.29 (0.35–4.72)0.75
3641.85 (0.42–8.11)0.45734.43 (0.73–26.76)0.121002.26 (0.01–5.03)0.57
40213.42 (0.59–306.10)0.090245.00 (1.78—1,140.00)0.02201.07 (0.05–25.56)1.00

NOTE: The risk alleles refer to −216T, Intron 1 CA-19, and 497R (G).