Table 1.

Dose–responses of NMC cell lines to treatment with 9 structurally different HDAC inhibitors

AcLys EC50 (μmol/L)Viability IC50 (μmol/L)
RankCompoundTC-79700-143Ty-82TC-79700-143Ty-82PER-40310326
1LBH-5890.0100.0260.0090.0060.0360.0090.0380.001
2TSA0.0020.0310.0150.0030.0430.0150.0250.003
3CRA-0247810.070.420.170.040.440.200.350.07
4ITF-23571.711.280.570.031.170.521.140.13
5PXD1010.281.380.880.042.090,680.480.21
6SAHA0.212.451.480.263.021.781.940.65
7MGCD01031.293.470.870.323.541.442.380.18
8MS-2750.574.091.960.284.742.965.560.39
9CI-9943.228.210.13.319.915.319.32.1

Abbreviations: AcLys, nuclear acetyl-lysine; EC50, concentration of drug that increases nuclear acetylation by 50% (1.5-fold induction) relative to vehicle control; IC50, concentration of drug that results in a 50% reduction in cell number relative to vehicle control.

TC-797, 00-143, Ty-82, PER-403, NMC cell lines which express BRD4-NUT.

10326, NMC cell line which expresses BRD3-NUT.