Table 2.

Results for top SNPs in CGEMS Stage II grouped by conditional scans and ranked by interaction P values (< 1.0E-4)

Interacting regionMultiplicative interaction
Conditioning regionSNPMAFChr, GeneMarginala OR (95% CI)OR (95% CI)P
CTPB2rs77653790.1260.99 (0.90, 1.09)0.80 (0.71, 0.89)9.83E-05
DAB2IPrs42420.32221.03 (0.97, 1.11)1.18 (1.10, 1.28)1.37E-05
EEFSECrs124894040.423, GRM70.99 (0.93, 1.05)0.85 (0.79, 0.91)3.10E-06
rs104584660.4910.97 (0.91, 1.03)1.15 (1.07, 1.24)6.52E-05
EHBP1rs105141240.3551.00 (0.93, 1.06)0.83 (0.76, 0.90)1.91E-05
rs7046380.3140.97 (0.90, 1.03)1.19 (1.10, 1.30)4.13E-05
rs76048090.122, GTF3C31.00 (0.91, 1.10)1.27 (1.13, 1.42)5.05E-05
HNF1Brs105066780.43121.00 (0.94, 1.07)1.14 (1.07, 1.22)5.35E-05
rs6171820.4617, PHOSPHO10.95 (0.89, 1.01)1.15 (1.07, 1.23)7.14E-05
rs46912380.4140.95 (0.90, 1.02)1.14 (1.07, 1.22)8.37E-05
JAZF1rs7457200.1920.96 (0.88, 1.03)1.23 (1.12, 1.35)2.28E-05
rs28997480.3515, GLCE0.96 (0.90, 1.02)0.84 (0.77, 0.91)3.04E-05
KLK2, KLK3rs15588740.129, PRRX21.05 (0.95, 1.16)1.33 (1.16, 1.53)4.80E-05
rs121966770.106, PNPLA10.94 (0.85, 1.05)1.37 (1.18, 1.60)5.88E-05
MSMBrs109353170.4230.98 (0.92, 1.05)1.14 (1.07, 1.22)3.93E-05
rs126054150.38180.99 (0.93, 1.06)1.14 (1.07, 1.22)6.20E-05
rs110832710.32181.02 (0.96, 1.09)1.16 (1.08, 1.24)6.67E-05
rs98808310.313, LOC3915241.04 (0.97, 1.12)0.87 (0.82, 0.93)6.90E-05
rs79216510.2310, FAM107B1.03 (0.97, 1.12)0.86 (0.79, 0.93)8.62E-05
MYEOVrs12402240.30121.03 (0.96, 1.10)1.15 (1.07, 1.23)9.00E-05
8q24 Region 1rs46604030.211, LOC3886210.93 (0.86, 1.01)1.24 (1.12, 1.38)7.57E-05
8q24 Region 2rs9910000.2621.03 (0.96, 1.11)0.83 (0.76, 0.91)4.97E-05
rs9433230.3014, KIAA14091.01 (0.95, 1.08)1.18 (1.09, 1.28)9.60E-05
8q24 Region 3rs49533470.482, EPAS10.97 (0.91, 1.04)1.13 (1.06, 1.21)9.69E-05
8q24 Region 4rs115893380.101, TMCO40.94 (0.84, 1.05)1.30 (1.15, 1.47)1.57E-05

Abbreviation: Chr, chromosome.

aMarginal results are based on single-SNP analyses.