Table 1.

Ki values for ureido-sulfonamide and glycosyl coumarin inhibitors of CAIX

CompoundKi (nmol/L)*
CAICAIICAIXCAXII
U-1045,0809,64045.14.5
GC-204>100,000>100,0009.243
GC-205>100,000>100,000201184

*Ki values were derived by using in vitro assays for CA activity as described in ref. 47.