Table 2.

Patient characteristics

No. of patients24
Age, y
Eastern Cooperative Oncology Group performance status
Tumor types
 Endometrial cancer2
 Hurthle cell thyroid1
No. of lines of prior systemic therapies (range 2–14)b
  • aPleural mesothelioma, hepatocellular, non-Hodgkin's lymphoma (low grade), external ear adenocarcinoma, bile duct adenocarcinoma, small cell lung cancer, esophageal adenocarcinoma, and chondrosarcoma.

  • bBecause of the observed myelosuppression, we enrolled less heavily pretreated patients (3 prior therapies or less) on Schedules B and C (patient 13 onwards).