Table 2.

Patient characteristics

No. of patients24
 Male13
 Female11
Age, y
 Median57
 Range25–77
Eastern Cooperative Oncology Group performance status
 01
 123
Tumor types
 Colorectal5
 Ovarian5
 Melanoma2
 Pancreas1
 Endometrial cancer2
 Hurthle cell thyroid1
 Othera8
No. of lines of prior systemic therapies (range 2–14)b
 2–314
 >310
  • aPleural mesothelioma, hepatocellular, non-Hodgkin's lymphoma (low grade), external ear adenocarcinoma, bile duct adenocarcinoma, small cell lung cancer, esophageal adenocarcinoma, and chondrosarcoma.

  • bBecause of the observed myelosuppression, we enrolled less heavily pretreated patients (3 prior therapies or less) on Schedules B and C (patient 13 onwards).