Table 1.

Hypoxia-responsive genes

In vitro derived genesIncluded in hypoxia classifierFunction
ADMADMStress response
AK3L1Nucleotide metabolism
ALDOAALDOAGlucose metabolism
ANKRD37ANKRD37Protein–protein interactions
ARRDC3Cell surface metabolism
BNIP3BNIP3Apoptosis
BNIP3LBNIP3LApoptosis
C3orf28C3orf28Unknown
C18orf19Unknown
CCNG2Cell cycle regulation
EGLN1Regulation of HIF-1 activity
EGLN3EGLN3Regulation of HIF-1 activity
ERO1LOxidoreductase
FOSL2Cell proliferation
GPIGlucose metabolism
HIG2Stress response
IGFBP3Cell proliferation
JMJD1AHistone demethylase
KCTD11KCTD11Apoptosis
LOC401152Unknown
LOXLOXExtracellular-matrix metabolism
NDRG1NDRG1Stress response
P4HA1P4HA1Extracellular-matrix metabolism
P4HA2P4HA2Extracellular-matrix metabolism
PDK1PDK1Energy metabolism
PFKFB3PFKFB3Glucose metabolism
RORAUnknown
SLC2A1SLC2A1Glucose metabolism
SLC6A8Glucose metabolism
CA9 apH regulation
  • aGene based on previous studies.