Table 1.

Summary of in vitro growth assays

Cell lineVectorCrizotinib IC50 (nmol/L)TAE684 IC50 (nmol/L)
Ba/F3EML4-ALK68 ± 43 ± 1
Ba/F3EML4-ALK L1152R853 ± 2766 ± 6
H3122GFP88
H3122EML4-ALK70
H3122EML4-ALK L1152R260
H3122EML4-ALK C1156Y240
H3122EML4-ALK L1196M240
H3122EML4-ALK F1174L620
DFCI0761,008 ± 37296 ± 29
DFCI076+PF299804 (1 μmol/L)314 ± 37
H31221007 ± 2
H3122 TR32,564 ± 107291 ± 18