Table 3.

Hypermethylated loci previously identified in breast cancers

Gene symbolPublishedHyper- methylated in other cancersKnown aberrant expressionGeneLocation
EVI1 (MECOM)ER+ (25, 39)NoBasal (40)MDS1 and EVI1 complex locusNucleus
ETS1ER+ (25)Basal (38)v-ets erythroblastosis virus E26 oncogene homologue 1Nucleus
IRF7ER+ (25)YesInterferon regulatory factor 7Nucleus
LYNER+ (25)YesBasal (38, 41, 42)v-yes-1 Yamaguchi sarcoma viral related oncogene homologCytoplasm
PDXKER+ (29)NoPyridoxal kinase (vitamin B6 kinase)Cytoplasm
PTGS2 (COX2)ER+ (25)YesBasal (38)Prostaglandin-endoperoxide synthase 2Cytoplasm
RUNX3ER+ (43)YesBasal (38)Runt-related transcription factor 3Nucleus
VIMER+YesBasal (41)VimentinCytoplasm
DAB2IP (4 loci)ER (25)YesDAB2 interacting proteinPlasma Membrane
HSD17B4ER (44)YesER+ (44)Hydroxysteroid (17-β) dehydrogenase 4Cytoplasm
PER1ER (23)Period homologue 1 (Drosophila)Nucleus