Table 2.

Hypermethylated loci newly identified in breast cancers

Gene symbolIdentified in this studyHyper- methylated in other cancersKnown aberrant expressionGeneLocation
ACADLER+NoNoAcyl-CoA dehydrogenase, long chainCytoplasm
ADAMTSL1ER+NoNoADAMTS-like 1Extracellular
ARFGAP3ER+NoNoADP-ribosylation factor GTPase activating protein 3Cytoplasm
B3GAT1ER+NoNoβ-1,3-Glucuronyltransferase 1Cytoplasm
CDCA7ER+NoER (37)Cell division cycle associated 7Nucleus
FAM78AER+NoNoFamily with sequence similarity 78, member AUnknown
FAM89AER+NoNoFamily with sequence similarity 89, member AUnknown
FLJ31951 (RNF145)ER+NoBASAL (38)UnknownUnknown
FLJ34922 (SLFN11)ER+NoNoSchlafen family member 11Nucleus
GAS6ER+NoNoGrowth arrest–specific 6Extracellular
HAAOER+NoNo3-Hydroxyanthranilate 3,4-dioxygenaseCytoplasm
HEY2ER+NoNoHairy/enhancer-of-split related with YRPW motif 2Nucleus
HOXB9ER+NoNoHomeobox B9Nucleus
ITGA11ER+NoNoIntegrin, alpha 11Plasma membrane
NETOER+NoNoNeuropilin (NRP) and tolloid (TLL)-like 2Unknown
PROX1ER+NoNoProspero homeobox 1Nucleus
PSAT1ER+NoBASAL (38)Phosphoserine aminotransferase 1Cytoplasm
RECKER+YesNoReversion-inducing cysteine-rich protein with kazal motifsPlasma membrane
SMOC1ER+NoNoSPARC related modular calcium binding 1Extracellular
SND1ER+NoNoStaphylococcal nuclease and tudor domain containing 1Nucleus
TNFSF9ER+YesNoTNF (ligand) superfamily, member 9Extracellular
ADHFE1ERYesNoAlcohol dehydrogenase, iron containing, 1Unknown
DYNLRB2ERNoNoDynein, light chain, roadblock-type 2Cytoplasm
HSD17B8ERNoNoHydroxysteroid (17-beta) dehydrogenase 8Cytoplasm
PISDERNoNoPhosphatidylserine decarboxylaseCytoplasm
PDXK (C21orf124)ERNoNoPyridoxal kinase (vitamin B6 kinase)Cytoplasm
WNK4ERNoNoWNK lysine deficient protein kinase 4Plasma membrane