Table 1.

Tumor spectrum of K-rasLA1 p53515A/515A and K-rasLA1 p53−/− mice

Tumor typeK-ras LA1 p53515A/515A (%)K-ras LA1 p53−/ (%)
Adenocarcinoma31 (55.4)5 (27.8)
 Adenocarcinoma (multifocal)18 (32.1)4 (22.2)
 Early adenocarcinoma (multifocal)7 (12.5)0
 Early adenocarcinoma (multifocal) + Lymphoma2 (3.6)1 (5.6)
 Metastatic adenocarcinoma2 (3.6)0
 Poorly differentiated adenocarcinoma2 (3.6)0
Sarcoma14 (25)8 (44.4)
 Osteosarcoma2 (3.6)0
 Angiosarcoma (mutifoocal)2 (3.6)2 (11.1)
 Spindle cell sarcoma (high grade)8 (3.6)4 (22.2)
 Sarcoma in soft tissue (high grade)2 (3.6)1 (5.6)
 Metastatic sarcoma in lung01 (5.6)
Lymphoma8 (14.3)5 (27.8)
 Carcinoma (teratocarcinoma)1 (1.8)0
 Others (hemorrhage liver or arm)2 (3.6)0
Total tumor:total mice (# of tumors per mouse)56:26 (2.15)18:8 (2.25)