Table 2.

Associations of breast cancer outcomes with the top two SNPsa

SNPStageNo. of eventsAll participantsPer allele HR (95% CI)Heterozygous HR (95% CI)Homozygous HR (95% CI)Ptrend
Total mortality
rs3784099 (A/G, 0.13)bDiscovery2761,4361.79 (1.46–2.19)1.77 (1.37–2.28)3.31 (1.92–5.71)1.44 × 10−08
Replication3383,8091.22 (0.99–1.52)1.14 (0.89–1.47)2.05 (1.05–4.00)6.44 × 10−02
Combined6145,2451.49 (1.28–1.72)1.41 (1.18–1.68)2.64 (1.74–4.03)1.17 × 10−07
Recurrence
rs3784099 (A/G, 0.13)bDiscovery3431,4051.73 (1.43–2.09)1.69 (1.34–2.13)3.20 (1.86–5.50)1.75 × 10−08
Replication4563,8091.20 (0.99–1.46)1.06 (0.84–1.34)2.32 (1.33–4.05)7.05 × 10−02
Combined7995,2141.43 (1.25–1.64)1.32 (1.12–1.55)2.69 (1.82–3.96)2.83 × 10−07
Total mortality
rs9934948 (C/T, 0.46)bDiscovery2761,4361.45 (1.23–1.71)1.37 (1.01–1.85)2.09 (1.51–2.90)9.71 × 10−06
Replication3383,8071.18 (1.02–1.37)1.29 (0.99–1.68)1.40 (1.03–1.90)2.76 × 10−02
Combined6145,2431.29 (1.16–1.44)1.31 (1.08–1.60)1.67 (1.34–2.09)5.75 × 10−06
Recurrence
rs9934948 (C/T, 0.46)bDiscovery3431,4051.37 (1.18–1.59)1.26 (0.96–1.65)1.86 (1.38–2.49)4.20 × 10−05
Replication4573,8071.07 (0.93–1.23)1.11 (0.88–1.40)1.14 (0.87–1.50)3.24 × 10−01
Combined8005,2121.19 (1.08–1.31)1.16 (0.98–1.39)1.41 (1.16–1.73)7.32 × 10−04
  • aAdjusted for age at diagnosis.

  • bEffect allele/reference allele, effect allele frequency, all SNPs were coded on the forward strand.