Tumor growth inhibition in nude mice bearing established Calu-6 human tumor xenografts
| Inhibition of tumor growth, % | ||
|---|---|---|
| Tumor model | AZD4547 | Cediraniba |
| LoVo | 0 | 63 |
| HCT-15 | 4.7 | 82b |
NOTE: Mice were treated orally, twice daily with AZD4547 (6.25 mg/kg) for 14 to 17 days or cediranib (LoVo, 1.5 mg/kg; Calu-6, 6 mg/kg; HCT-15, 6 mg/kg) once daily for up to 28 days. Percentage of tumor growth inhibition was calculated as the difference between the mean change in control versus treated tumor volumes over the period of treatment.