Table 1.

Canonical pathways in Notch-regulated transcriptome

MCF7OVCAR3
Ingenuity canonical pathwaysPRatioPRatio
MRK-003 downregulated
Cell-cycle control of chromosomal replication0.000.470.040.17
Pyrimidine metabolism0.000.130.040.14
ATM signaling0.000.190.000.15
Cyclins and cell-cycle regulation0.000.130.010.12
Breast Cancer Regulation by Stathmin10.000.090.030.08
Cell cycle: G2–M DNA damage checkpoint regulation0.000.170.000.21
Protein Ubiquitination Pathway0.000.070.020.08
Purine metabolism0.000.070.010.09
p53 Signaling0.000.110.020.11
Germ cell–sertoli cell junction signaling0.000.080.010.09
RAN signaling0.010.170.010.22
Prostate cancer signaling0.010.210.040.19
Molecular mechanisms of cancer0.020.250.020.07
Glycolysis/gluconeogenesis0.050.310.010.12
Antiproliferative role of TOB in T-cell signaling0.050.340.000.27
MRK-003 upregulated
Biosynthesis of steroids0.000.290.000.33
Glycine, serine and threonine metabolism0.000.130.040.07
Production of nitric oxide and reactive oxygen species in macrophages0.000.090.030.06
TR/RXR activation0.020.130.010.08
Metabolism of xenobiotics by cytochrome P4500.020.140.040.07