Table 3.

The performance of Ld on an independent training (n = 87) and testing set (n = 39) developed for controls and patients having advanced adenoma

Training set (%); N = 87 patientsValidation set (%); N = 39 patients
Sensitivity7374
Specificity7883
PPV41N/A
NPV93N/A

NOTE: Sensitivity, specificity, PPV, NPV are shown for controls and patients having advanced adenoma in their colon using the training set. On the basis of a single cutoff Ld value derived from the training set, we obtained equivalent performance characteristics (i.e., sensitivity and specificity) for the enriched testing set. As the testing data set is an enriched population, predictive values (both negative and positive) are uninformative.