Table 1.

Relative binding affinity of GD3 to human and mouse CD1d molecules

Ligand (competitor)IC50 in hCD1d, nmol/LIC50 in mCD1d, nmol/L
18:1 PE lipid882 ± 125843 ± 181
GD3 (CHCl3 + CH3OH)24.6 ± 3.210.5 ± 1.5
α-GalCer84.0 ± 10.095.1 ± 18.3