Table 1.

The associations of the HDMXS/HDMX-FL ratios with p53 pathway mutations in 3 cell panels

Ratio S/FL
Osteosarcoma
 p53 (n = 22)wt (n = 6)1.17
Mut (n = 16)1.84
P0.0325a
 wt p53 (n = 6)Low HDM2 (n = 3)0.83
High HDM2 (n = 3)1.51
P0.1a
Breast cancer
 p53 (n = 37)wt (n = 8)0.69
Mut (n = 29)1.76
P0.0028a
 wt p53 (n = 8)Low HDM2 (n = 4)0.34
High HDM2 (n = 4)1.03
P0.343a
NCI60
 p53 (n = 50)wt (n = 14)1.47
Mut (n = 36)2.71
P0.0227a
 wt p53 (n = 14)Low HDM2 (n = 7)0.57
High HDM2 (n = 7)2.38
P0.0728a
0.0364b
All cell lines
 p53 (n = 106)wt (n = 27)1.22
Mut (n = 79)2.24
P0.0001a
 wt p53 (n = 27)Low HDM2 (n = 13)0.56
High HDM2 (n = 14)1.93
P0.0116a
  • aMann–Whitney test, 2-tail.

  • bMann–Whitney test, 1-tail.