Table 1.

Patient and tumor characteristics in relation to HPV16 status studied on OPSCC collected between 1990 and 2008 in Heidelberg, Germany

HPV16 status
TotalHPVHPV+HPVtransfHPVtransf+
N = 196N = 99N = 97N = 54N = 42
Characteristicsn (%)n (%)n (%)n (%)n (%)
Gender
 Male146 (74)79 (80)67 (69)39 (72)27 (64)
 Female50 (26)20 (20)30 (31)15 (28)15 (36)
Age, y
 Median57.056.757.456.162.1
Oropharynx subsite
 Tonsils84 (43)33 (33)51 (53)29 (54)21 (50)
 Base of tongue45 (23)27 (27)18 (19)7 (13)11 (26)
 Othera67 (34)39 (40)28 (28)18 (33)10 (24)
Tumor size
 T1–T287 (45)44 (45)43 (45)20 (37)23 (56)
 T3–T4107 (55)54 (55)53 (55)34 (63)18 (44)
 Missing2111
Lymph nodes
 N047 (24)24 (24)23 (24)18 (33)5 (12)
 N+147 (76)74 (76)73 (76)36 (67)36 (88)
 Missing2111
Distant metastasis
 M0179 (95)93 (95)86 (96)47 (92)38 (100)
 M19 (5)5 (5)4 (4)4 (8)0 (0)
 Missing81734
Clinical stage
 I–III60 (31)33 (34)27 (28)20 (37)7 (17)
 IV134 (69)65 (66)69 (72)34 (63)34 (83)
 Missing2111
First-line therapy
 Surgery125 (68)59 (64)66 (72)32 (63)33 (83)
 Radiation/chemotherapy59 (32)33 (36)26 (28)19 (37)7 (17)
 Missing127532
Tobacco
 Never21 (11)6 (6)15 (16)0 (0)15 (37)
 Former20 (10)9 (9)11 (11)6 (11)5 (12)
 Current153 (79)83 (85)70 (73)48 (89)21 (51)
 Missing2111
Alcohol
 Never15 (8)9 (9)6 (6)2 (4)4 (10)
 Former23 (12)18 (18)5 (5)4 (8)1 (2)
 Current155 (80)71 (73)84 (89)47 (88)36 (88)
 Missing31211

Abbreviations: HPV, HPV16 DNA negative analyzed by BSGP5+/6+-PCR/MPG; HPV+, HPV16 DNA positive analyzed by BSGP5+/6+-PCR/MPG; HPVtransf, HPV+ with low viral load analyzed by qPCR, but without CxCa-like viral RNA patterns; HPVtransf+, HPV+ with high viral load analyzed by qPCR and/or CxCa-like viral RNA patterns.

  • aNineteen palate, 18 extending outside oropharynx (hypopharynx, nasopharynx, and/or larynx), 11 uvula, 19 unspecified.