Table 2.

Types of PIK3CA and KRAS mutations

Mutation typeN (%)
PIK3CA mutationsa105
 N345K1 (<1)
 E542K19 (18)
 E542V1 (<1)
 E545K35 (33)
 E545A1 (<1)
 E545G2 (2)
 Q546K2 (2)
 Q546P1 (<1)
 Q546R1 (<1)
 S553N1 (<1)
 P539R, E545A1 (<1)
 E545K, D549H1 (<1)
 Exon 9 deletion1 (<1)
 E545A, H1047Y1 (<1)
 Y1021C1 (<1)
 R1023Q1 (<1)
 T1025A2 (2)
 M1043I2 (2)
 M1043V2 (2)
 N1444K1 (<1)
 D1045N1 (<1)
 H1047L4 (4)
 H1047R20 (19)
 G1049R3 (3)
KRASb mutations137
 G12A12 (9)
 G12C12 (9)
 G12D41 (30)
 G12F1 (<1)
 G12R5 (4)
 G12S5 (4)
 G12V26 (19)
 G13C1 (<1)
 G13D18 (13)
 Q61H5 (4)
 Q61L2 (1)
 Not specified9 (7)
  • aTested for PIK3CA, N = 1,012

  • bTested for KRAS, n = 717