Table 1.

Cytotoxicity of hSGZ on breast cancer cell lines

IC50, nmol/L
Cell linesFn14 receptorHER2 receptorrGelhSGZTargeting indexa
eB1+++8350.18,350
MDA-MB-231+++−−7450.17,450
SKBr-3+++++1,5500.62,538
MCF7/HER2++++++4410.7 P < 0.05 (MCF7/HER2 vs. MCF7)630
MCF7+−−4522.4188
BT-474/HR−−+++590489 n.s. (BT-474/HR vs. BT-474)∼1
BT-474−−+++945>489<2
  • Abbreviation: n.s., not statistically significant (P > 0.05).

  • aTargeting index represents IC50 of rGel/IC50 of hSGZ. Student t test was used to calculate P value. Data are representative of three independent experiments.