Table 1.

Summary of maximum toxicities related to anti-OX40 at all dose levels

Adverse events
ToxicityGrade 1Grade 2Grade 3Grade 4
Lymphopenia31061
Fatigue712
Rash/skin changes46
Pruritis51
Fever/chills112
Splenomegaly7
Arthralgias/myalgias55
Nausea/vomiting43
Increased AST, ALT, or alkaline phosphatase21
Anemia18

NOTE: Patients with multiple instances of the same toxicity were tabulated once with the highest grade for that toxicity.