HRs and 95% CIs for breast cancer associated with solvent job exposure by estrogen receptor status
| ER+ tumors | ER− tumors | |||||
|---|---|---|---|---|---|---|
| Casesa | Casesa | |||||
| N = 968 | Adjusted | N = 197 | Adjusted | |||
| Person-years | n (%) | HRb (95% CI) | Person-years | n (%) | HRb (95% CI) | |
| Solvent job | ||||||
| Ever | 30,373 | 132 (14) | 1.15 (0.95–1.39) | 30,373 | 27 (14) | 0.91 (0.58–1.43) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Total duration of solvent job(s) exposure, y | ||||||
| 10+ | 12,584 | 59 (6) | 1.20 (0.92–1.57) | 12,584 | 14 (7) | 1.07 (0.58–1.97) |
| 5 to <10 | 7,368 | 32 (3) | 1.20 (0.83–1.71) | 7,368 | 4 (2) | 0.35 (0.09–1.40) |
| 1 to <5 | 10,422 | 41 (4) | 1.06 (0.77–1.46) | 10,422 | 9 (5) | 1.11 (0.57–2.19) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Trendc | P = 0.62 | P = 0.75 | ||||
| Frequency of solvent exposure | ||||||
| 1+/wk | 6,661 | 31 (3) | 1.12 (0.77–1.63) | 6,661 | 5 (3) | 0.55 (0.18–1.74) |
| <1/wk | 23,027 | 98 (10) | 1.16 (0.94–1.44) | 23,027 | 22 (11) | 1.05 (0.65–1.70) |
| Never | 194,930 | 836 (87) | Ref | 194,930 | 170 (86) | Ref |
| Time period of first solvent job | ||||||
| Before 1980 | 14,893 | 80 (8) | 1.28 (1.01–1.62) | 14,893 | 16 (8) | 1.01 (0.57–1.79) |
| 1980 and after | 15,440 | 52 (5) | 1.00 (0.75–1.34) | 15,440 | 11 (6) | 0.80 (0.40–1.57) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Time since last solvent job at baseline interview | ||||||
| 5+ y | 20,169 | 96 (10) | 1.22 (0.98–1.51) | 20,169 | 16 (8) | 0.74 (0.41–1.34) |
| Current to <5 y | 10,164 | 36 (4) | 1.01 (0.72–1.42) | 10,164 | 11 (6) | 1.27 (0.66–2.42) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Age at first solvent job at baseline interview | ||||||
| 35+ y | 7,328 | 33 (3) | 1.14 (0.80–1.62) | 7,328 | 7 (4) | 1.00 (0.44–2.27) |
| 25 to <35 y | 8,445 | 32 (3) | 1.00 (0.70–1.45) | 8,445 | 8 (4) | 1.02 (0.48–2.19) |
| 20 to <25 y | 7,903 | 34 (4) | 1.14 (0.80–1.62) | 7,903 | 4 (2) | 0.32 (0.08–1.30) |
| <20 y | 6,658 | 33 (3) | 1.38 (0.97–1.97) | 6,658 | 8 (4) | 1.40 (0.65–2.99) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Trendc | P = 0.54 | P = 0.68 | ||||
| Timing of first solvent job | ||||||
| Before first birth | 9,612 | 48 (5) | 1.39 (1.03–1.86) | 9,612 | 8 (4) | 1.00 (0.47–2.15) |
| After first birth | 14,497 | 57 (6) | 1.06 (0.79–1.41) | 14,497 | 15 (8) | 0.90 (0.48–1.68) |
| Nulliparous | 6,189 | 27 (3) | 1.03 (0.69–1.54) | 6,189 | 4 (2) | 0.82 (0.29–2.29) |
| Never | 194,930 | 836 (86) | Ref | 194,930 | 170 (86) | Ref |
| Duration of solvent job(s) exposure relative to first birthd | ||||||
| 5+ y before first birth | 3,045 | 18 (2) | 1.56 (0.97–2.50) | 3,045 | 2 (1) | 0.91 (0.22–3.73) |
| 3 to <5 y before first birth | 2,763 | 13 (2) | 1.28 (0.74–2.23) | 2,763 | 5 (3) | 1.98 (0.73–5.37) |
| <3 y before first birth | 3,804 | 17 (2) | 1.14 (0.70–1.88) | 3,804 | 1 (1) | 0.33 (0.05–2.38) |
| After first birth | 14,497 | 57 (7) | 1.05 (0.79–1.40) | 14,497 | 15 (9) | 0.88 (0.47–1.65) |
| Never | 159,475 | 689 (87) | Ref | 159,475 | 141 (86) | Ref |
| Trendc | P = 0.05 | P = 0.76 | ||||
NOTE: Differences in the total numbers of cases are due to missing values. Significant values (<0.05) are in bold font.