Name | Value | Units | Description | Reference |
---|---|---|---|---|

Plasma PK model parameters | ||||

For free irinotecan | ||||

Cl_{CPT-11} | 1.222e−4 | L/min | Plasma clearance rate of CPT-11 | Estimated |

Cl_{SN-38} | 2.138e−5 | L/min | Plasma clearance rate of SN-38 | Estimated |

k_{12,CPT-11} | 8.444e−5 | 1/min | Rate of CPT-11 transport from plasma to peripheral compartment | Estimated |

k_{21,CPT-11} | 4.213e−2 | 1/min | Rate of CPT-11 transport from peripheral to plasma compartment | Estimated |

k_{12,SN-38} | 2.656e−5 | 1/min | Rate of CPT-11 transport from plasma to peripheral compartment | Estimated |

k_{21,SN-38} | 3.44e−4 | 1/min | Rate of CPT-11 transport from peripheral to plasma compartment | Estimated |

V_{max,CES,p} | 2.263e−1 | nmol/min | Maximum rate coefficient for CES enzyme in plasma compartment | Estimated |

K_{m,CES,p} | 2.67e5 | nmol/L | Michaelis-Menten constant for CES enzyme in plasma compartment | Estimated |

V_{p} | 9.46e−5 | L | Volume of plasma compartment | Estimated |

V_{ph} | 0.02 | L | Volume of peripheral compartment | Fixed (14) |

For nal-IRI | ||||

Cl_{nal-IRI} | 1.87e−7 | L/min | Plasma clearance rate of nal-IRI | Estimated |

Cl_{CPT-11} | 1.634e−5 | L/min | Plasma clearance rate of CPT-11 | Estimated |

Cl_{SN-38} | 2.957e−6 | L/min | Plasma clearance rate of SN-38 | Estimated |

k_{12,CPT-11} | 1.619e−4 | 1/min | Rate of CPT-11 transport from plasma to peripheral compartment | Estimated |

k_{21,CPT-11} | 5.349e−7 | 1/min | Rate of CPT-11 transport from peripheral to plasma compartment | Estimated |

V_{max,Release,p} | 8.443e−6 | nmol/min | Maximum rate coefficient for CPT-11 release from nal-IRI in plasma compartment | Estimated |

K_{m,Release,p} | 2.04 | nmol/L | Michaelis-Menten constant for CPT-11 release from nal-IRI in plasma compartment | Estimated |

V_{max,CES,p} | 5.943e−2 | nmol/min | Maximum rate coefficient for CES enzyme in plasma compartment | Estimated |

K_{m,CES,p} | 1.198e−5 | nmol/L | Michaelis-Menten constant for CES enzyme in plasma compartment | Estimated |

V_{p} | 1.12e−3 | L | Volume of plasma compartment | Estimated |

V_{ph} | 0.02 | L | Volume of peripheral compartment | Fixed (14) |

Tumor deposition model parameters | ||||

Q_{tumor} | 2.119e−6 | L/min | Blood flow rate to tumor | (14) |

PS_{nal-IRI} | 7.858e−5 | L/min/kg | Tissue permeability coefficient of nal-IRI | Estimated |

PS_{CPT-11} | 1.851e−3 | L/min/kg | Tissue permeability coefficient of CPT-11 | Estimated |

PS_{SN-38} | 2.687e−2 | L/min/kg | Tissue permeability coefficient of SN-38 | Estimated |

σ_{nal-IRI} | 3.181e−3 | Tissue-capillary partition coefficient of nal-IRI | Estimated | |

σ_{CPT-11} | 5.24e−1 | Tissue-capillary partition coefficient of CPT-11 | Estimated | |

σ_{SN-38} | 2.109e−1 | Tissue-capillary partition coefficient of SN-38 | Estimated | |

k_{Release,t} | 1.681e−4 | 1/min | Rate coefficient for CPT-11 release from nal-IRI in tumor tissue compartment | Estimated |

V_{max,CES,t} | 2.17e−2 | nmol/min | Maximum rate coefficient for CES enzyme in tumor tissue compartment | Estimated |

K_{m,CES,t} | 2.3e−6 | nmol/L | Michaelis-Menten constant for CES enzyme in tumor tissue compartment | Estimated |

V_{cap} | 7e−7 | L | Volume of tumor capillary compartment | (14) |

V_{t} | 1e−5 | L | Volume of tumor tissue compartment | Fixed |