Table 1.

Biodistribution of 68Ga-DOTA-C-(HE)3-ADAPT6 in BALB/C nu/nu mice bearing SKOV-3 xenografts (high HER2 expression) and LS174T (low HER2 expression) at 1 hour p.i.

SKOV3 xenograftsLS174T xenografts
1 μg15 μg1 μg15 μg
Blood0.59 ± 0.070.50 ± 0.060.60 ± 0.090.6 ± 0.2
Lung0.70 ± 0.020.53 ± 0.060.67 ± 0.090.7 ± 0.2
Liver1.7 ± 0.11.21 ± 0.051.8 ± 0.11.6 ± 0.1
Spleen0.62 ± 0.050.50 ± 0.070.74 ± 0.070.56 ± 0.34
Stomach0.63 ± 0.110.35 ± 0.070.54 ± 0.060.36 ± 0.09
Kidney308 ± 24277 ± 5323 ± 27311 ± 31
Tumor10.3 ± 1.0a, c8.4 ± 0.6d2.9 ± 0.5b0.9 ± 0.6
Muscle0.18 ± 0.010.12 ± 0.020.14 ± 0.020.14 ± 0.03
Bone0.5 ± 0.10.34 ± 0.070.5 ± 0.10.4 ± 0.1

NOTE: Data are presented as an average %IA/g and SD for four mice.

Difference was significant (P < 0.05) between:

  • aInjected dose of 1 and 15 μg in SKOV3 xenografts.

  • bInjected dose of 1 and 15 μg in LS174T xenografts.

  • cSKOV3 and LS174T xenografts at injected dose of 1 μg.

  • dSKOV3 and LS174T xenografts at injected dose of 15 μg.