Table 2.

Tumor-to-organ ratios of 68Ga-DOTA-C-(HE)3-ADAPT6 in BALB/C nu/nu mice bearing SKOV-3 xenografts (high HER2 expression) and LS174T (low HER2 expression) at 1 hour p.i.

SKOV3 xenograftsLS174T xenografts
1 μg15 μg1 μg15 μg
Blood17.5 ± 0.317 ± 24.8 ± 0.21.5 ± 0.8
Lung15 ± 116 ± 14.3 ± 0.21.4 ± 0.7
Liver6.0 ± 0.17.0 ± 0.41.6 ± 0.20.6 ± 0.4
Spleen17 ± 217 ± 13.9 ± 0.42.1 ± 1.0
Stomach16 ± 124 ± 45 ± 12 ± 1
Kidney0.034 ± 0.0050.030 ± 0.0030.009 ± 0.0020.003 ± 0.002
Muscle56 ± 970 ± 621 ± 47 ± 4
Bone20 ± 425 ± 47 ± 32 ± 1

NOTE: Data are presented as an average value and SD for four mice.