Table 1.

Dosimetric calculations

177Lu-anti-PD-L190Y-anti-PD-L1111In-anti-PD-L1
TissueAD (mGy/MBq)AD (mGy/MBq)AD (mGy/MBq)
Spleen2.58.20.7
Liver0.82.70.3
Thymus0.72.20.1
Kidneys0.31.10.1
Red marrow0.10.30.02
Tumor1.13.00.2

NOTE: Dosimetric calculations expressed in mGy per injected MBq for the spleen, liver, thymus, kidneys, red marrow, and tumor for anti–PD-L1 antibodies labeled with the therapeutic beta particle emitters 177Lu and 90Y, and the diagnostic imaging radionuclide 111In. The AD calculated for normal tissues and tumors was based on neu-N mouse biodistribution data, which were converted into adult human ADs. The calculated time-integrated activities were used as input in OLINDA/EXM using the adult male phantom for normal tissues, and using the sphere model to calculate the AD for the tumor.