Table 1.

Characteristics of 1,008a breast cancer cases according to rs45446698 genotype

rs45446698 A:C + C:Crs45446698 A:A
n = 73n = 935Pb
Mean age55.056.1
Age range27–8224–890.44
Tumor size group (cm)
 <244 (60.3)521 (55.7)
 2–523 (31.5)363 (38.8)
 5+6 (8.2)51 (5.5)0.35
Grade
 111 (15.1)155 (16.6)
 236 (49.3)435 (46.5)
 326 (35.6)345 (36.9)0.89
ER status
 Positive64 (87.7)789 (84.4)
 Negative9 (12.3)146 (15.6)0.45
Positive nodes
 030 (41.1)498 (53.3)
 1–317 (23.3)239 (25.6)
 4+19 (26.0)115 (12.3)
 N/A7 (9.6)83 (8.9)0.003
Vascular invasion
 Positive29 (39.7)315 (33.7)
 Negative41 (56.2)598 (64.0)
 N/A3 (4.1)22 (2.3)0.24
Surgery
 Yes72 (98.6)923 (98.7)
 No1 (1.4)12 (1.3)0.95
Radiotherapy
 Yes68 (93.1)808 (86.4)
 No5 (6.9)124 (13.3)
 N/A0 (0)3 (0.3)0.11
Chemotherapy
 Yes43 (58.9)481 (51.4)
 No30 (41.1)452 (48.3)
 N/A0 (0)2 (0.2)0.23
Tamoxifen
 Yes58 (79.5)736 (78.7)
 No15 (20.5)195 (20.9)
 N/A0 (0)4 (0.4)0.94
Pyrs4475625
Events19140
Rate (per 1,000 pyrs)42.5 (27.1–66.6)24.9 (21.1–29.4)0.02
  • aExcludes two women with missing genotype.

  • bTwo-sided t test (age), χ2 test (size, grade, ER status, positive nodes, vascular invasion, surgery, radiotherapy, chemotherapy, and tamoxifen), and log-rank test (events).