Table 4.

Chemotherapy regimens used in the treatment of breast cancer, lung cancer, and CLL cases

Breast cancer (cytotoxic treatment)aN treated (%)
Doxorubicin, cyclophosphamide173 (17.2)b
Cyclophosphamide, methotrexate, fluorouracil18 (1.8)
Epirubicin, cisplatin, fluorouracil13 (1.3)c
Fluorouracil, epirubicin, cyclophosphamide202 (20.0)d
Methotrexate, mitoxantrone93 (9.2)e
Vinorelbine, epirubicin21 (2.1)
Other/not known6 (0.6)
No cytotoxic treatment482 (47.8)
Total1,008 (100)
Breast cancer (hormonal treatment)a
Tamoxifen495 (49.1)
Tamoxifen, anastrozole128 (12.7)
Tamoxifen, letrozole171 (17.0)
Other/not known75 (7.4)f
No hormonal treatment139 (13.8)
Total1,008 (100)
Lung cancer
Cisplatin/carboplatin, etoposide206 (18.3)g
Cisplatin/carboplatin, vinorelbine/vincristin180 (16.0)h
Cisplatin/carboplatin, vinorelbine/vincristin, mitomycin133 (11.8)
Cisplatin/carboplatin, gemcitabine194 (17.2)
Cisplatin/carboplatin, taxane28 (2.5)
Doxorubicin, cyclophosphamide, vinorelbine/vincristin33 (2.9)
Doxorubicin, cyclophosphamide, etoposide11 (1.0)
Other/not known27 (2.4)
No cytotoxic treatment316 (28.0)
Total1,128 (100)
CLL
Chlorambucil166 (47.8)
Fludarabine88 (25.4)
Fludarabine, cyclophosphamide93 (26.8)
No cytotoxic treatment0 (0)
Total347 (100)

NOTE: Agents that are metabolized by a CYP3A enzyme are in bold.

  • aFor breast cancer, treatment with a cytotoxic agent and a hormonal agent were not mutually exclusive; 415 (41.2%) of the 1,008 cases were treated with both a cytotoxic agent and a hormonal agent.

  • bIncludes 19 women also treated with a taxane.

  • cIncludes one woman also treated with a taxane.

  • dIncludes 20 women also treated with a taxane.

  • eIncludes 14 women also treated with a taxane.

  • fComprises 41 women who were treated with anastrozole, 29 who were treated with letrozole, 1 who was treated with both and 4 for whom treatment details are not known.

  • gIncludes 4 individuals also treated with ifosfamide and 1 who was also treated with both ifosfamide and vincristine.

  • hIncludes 2 individuals also treated with ifosfamide.