Table 2

Associations of WC with liver cancer risk in LCPP

AllWomenMen
WC (cm)No. casesaMinimally adjustedMultivariable adjustedMultivariable adjustedNo. casesaMinimally adjustedMultivariable adjustedMultivariable adjustedNo. casesaMinimally adjustedMultivariable adjustedMultivariable adjusted
HR (95% CI)bHR (95% CI)cHR (95% CI)dHR (95% CI)bHR (95% CI)cHR (95% CI)dHR (95% CI)bHR (95% CI)cHR (95% CI)d
M < 90, F < 701201.00 (ref)1.00 (ref)1.00 (ref)191.00 (ref)1.00 (ref)1.00 (ref)1011.00 (ref)1.00 (ref)1.00 (ref)
M: 90–100, F: 70–802471.08 (0.87–1.35)1.15 (0.92–1.43)1.09 (0.86–1.37)551.08 (0.64–1.83)1.11 (0.66–1.87)1.11 (0.65–1.90)1921.09 (0.85–1.39)1.14 (0.89–1.46)1.05 (0.80–1.37)
M: 100–110, F: 80–902391.44 (1.15–1.80)1.55 (1.24–1.94)1.33 (1.02–1.72)761.36 (0.82–2.26)1.35 (0.82–2.25)1.27 (0.73–2.21)1631.43 (1.11–1.84)1.54 (1.19–1.98)1.27 (0.93–1.73)
M ≥ 110, F ≥ 902271.86 (1.48–2.35)1.93 (1.53–2.44)1.43 (1.05–1.94)1101.80 (1.10–2.95)1.76 (1.07–2.89)1.43 (0.79–2.61)1171.81 (1.38–2.39)1.88 (1.42–2.49)1.40 (0.97–2.03)
Per 5 cm1.11 (1.08–1.14)1.11 (1.08–1.14)1.08 (1.04–1.13)1.11 (1.07–1.16)1.11 (1.06–1.16)1.11 (1.04–1.18)1.10 (1.06–1.14)1.10 (1.07–1.14)1.07 (1.01–1.13)
Ptrende<0.001<0.0010.001<0.001<0.0010.001<0.001<0.0010.02
Pinteraction with sexf0.970.600.66
  • Abbreviations: F, females; M, males.

  • aSome counts do not add to totals because of missing data. Only 10 of the 14 cohorts in the LCPP contributed to WC analyses.

  • bAdjusted for age, sex, and study.

  • cAdjusted for age, sex, study, alcohol, cigarette smoking, and race.

  • dAdjusted for age, sex, study, alcohol, cigarette smoking, race, and BMI.

  • ePtrend from Wald tests.

  • fPinteraction with sex from log-likelihood ratio tests.