Table 1

Associations of BMI with liver cancer risk in LCPP

AllWomenMen
BMI (kg/m2)No. casesaMinimally adjustedMultivariable adjustedMultivariable adjustedNo. casesaMinimally adjustedMultivariable adjustedMultivariable adjustedNo. casesaMinimally adjustedMultivariable adjustedMultivariable adjusted
HR (95% CI)bHR (95% CI)cHR (95% CI)dHR (95% CI)bHR (95% CI)cHR (95% CI)dHR (95% CI)bHR (95% CI)cHR (95% CI)d
191.51 (0.96–2.39)1.40 (0.89–2.21)1.41 (0.89–2.23)111.46 (0.80–2.67)1.34 (0.73–2.46)1.35 (0.74–2.48)81.53 (0.76–3.08)1.44 (0.71–2.91)1.47 (0.73–2.96)
18.5–<255861.00 (ref)1.00 (ref)1.00 (ref)2541.00 (ref)1.00 (ref)1.00 (ref)3321.00 (ref)1.00 (ref)1.00 (ref)
25–<308611.20 (1.08–1.33)1.21 (1.09–1.35)1.17 (1.05–1.30)1911.07 (0.88–1.29)1.06 (0.88–1.29)1.03 (0.85–1.25)6701.27 (1.11–1.45)1.29 (1.13–1.48)1.24 (1.08–1.42)
30–<354391.86 (1.64–2.11)1.87 (1.65–2.13)1.68 (1.48–1.91)1221.65 (1.33–2.06)1.63 (1.30–2.03)1.49 (1.19–1.86)3171.98 (1.69–2.31)2.01 (1.72–2.36)1.80 (1.53–2.11)
35–<401402.41 (2.00–2.91)2.42 (2.01–2.92)2.05 (1.69–2.48)552.21 (1.64–2.96)2.16 (1.60–2.91)1.85 (1.36–2.51)852.51 (1.97–3.20)2.57 (2.01–3.28)2.19 (1.72–2.80)
≥40422.17 (1.58–2.98)2.16 (1.57–2.96)1.79 (1.30–2.45)181.70 (1.05–2.74)1.64 (1.01–2.66)1.37 (0.84–2.23)242.39 (1.56–3.68)2.46 (1.60–3.77)2.11 (1.38–3.22)
<18.5191.51 (0.95–2.39)1.40 (0.88–2.21)1.41 (0.89–2.23)111.46 (0.80–2.67)1.34 (0.73–2.46)1.35 (0.74–2.48)81.53 (0.76–3.08)1.44 (0.71–2.91)1.47 (0.73–2.96)
18.5–<255861.00 (ref)1.00 (ref)1.00 (ref)2541.00 (ref)1.00 (ref)1.00 (ref)3321.00 (ref)1.00 (ref)1.00 (ref)
25–<308611.20 (1.08–1.33)1.21 (1.09–1.35)1.17 (1.05–1.30)1911.07 (0.88–1.29)1.06 (0.88–1.29)1.03 (0.85–1.24)6701.27 (1.11–1.45)1.29 (1.13–1.48)1.24 (1.08–1.42)
≥306211.98 (1.76–2.22)1.99 (1.77–2.24)1.75 (1.56–1.98)1951.78 (1.47–2.15)1.75 (1.44–2.12)1.56 (1.27–1.90)4262.08 (1.80–2.41)2.12 (1.83–2.46)1.88 (1.61–2.18)
Per 5 kg/m2e1.33 (1.27–1.39)1.33 (1.27–1.39)1.26 (1.21–1.32)1.26 (1.18–1.35)1.25 (1.17–1.35)1.20 (1.11–1.29)1.37 (1.29–1.45)1.38 (1.30–1.46)1.31 (1.23–1.39)
Ptrendf<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001
Pinteraction with sexg0.040.020.02
  • aSome counts do not add to totals because of missing data.

  • bAdjusted for age, sex, and study.

  • cAdjusted for age, sex, study, alcohol, cigarette smoking, and race.

  • dAdjusted for age, sex, study, alcohol, cigarette smoking, race, and diabetes.

  • eContinuous BMI models exclude all participants <18.5 kg/m2.

  • fPtrend from Wald tests.

  • gPinteraction with sex from log-likelihood ratio tests.