Table 1.

Dysregulated pathways and their associated proteins in chemoresistant cells

Related pathwaysMass spec counts
SymbolGene nameUpregulatedH69ARH69H82DMS79Fold change
ITGB1Integrin, beta 1Integrin and PI3/AKT signaling24289861442.73
COL1A1Collagen, type I, alpha 1PI3/AKT signaling22100822,071.00
EIF4A1Eukaryotic translation initiation factor 4A1TGFβ2071982511.11
RPL3Ribosomal protein L3Infectious diseases14800914,771.00
COL1A2Collagen, type I, alpha 2PI3/AKT signaling147403234.09
MCAMMelanoma cell adhesion moleculeCell adhesion13520511076.73
ATICIMP cyclohydrolasePurine biosynthesis1251292210.29
LGALS1Lectin, galactoside-binding, soluble, 1NF-κB and MAPK signaling11630340.34
JAG1Jagged 1Notch signaling11403011,406.00
EPHA2EPH receptor A2PI3/AKT signaling980039,752.00
Downregulated
LMNB2Lamin B2PI3/AKT signaling242561102100.09
NCAM1Neural cell adhesion molecule 1Cell adhesion133421772680.04
SYNE2Spectrin repeat containing, nuclear envelope 2Cell cycle1011511220.08
TGM2Transglutaminase 2Phospholipase-C and CREB2111010.02
CNTN1Contactin 1Notch signaling13238800.00
NCAM2Neural cell adhesion molecule 2Cell adhesion0106060.00
FLNBFilamin B, betaMAPK signaling0156000.00
ACTA1Actin, alpha 1, skeletal muscleAKT signaling0160000.00
CES1Carboxylesterase 1Xenobiotic metabolism0174030.00
ALCAMActivated leukocyte cell adhesion moleculeCell adhesion0191232980.00