Table 1.

In vitro cytotoxicity of SNMs assembled in water as compared with free cabazitaxel dissolved in DMSO after 72-hour incubation (expressed as IC50 ± SD in nmol/L)a

IC50 (nmol/L)
Cell lineFree CTX1b2345
Bcap37Bare1.5 ± 0.210.8 ± 1.4c535.5 ± 2119,058 ± 1,61624,106 ± 1,50636,961 ± 2,930
PEGylated3.4 ± 0.4c168 ± 104,518 ± 5308,148 ± 84726,225 ± 2,711
MDA-MB-231Bare66.6 ± 4.9386.5 ± 18.6c742.7 ± 128.521,012 ± 1,00125,863 ± 1,33342,515 ± 3,651
PEGylated278.5 ± 35.4c460.4 ± 41.212,930 ± 1,11323,660 ± 1,36839,357 ± 2,216
DU145Bare2.0 ± 0.46.2 ± 0.9d317.7 ± 25.61,873 ± 2432,832 ± 2323,637 ± 217
PEGylated7.7 ± 0.9d182.1 ± 10.6267 ± 43428 ± 371,536 ± 161
LoVoBare20.9 ± 2.242.8 ± 4.4c1819 ± 13635,049 ± 1,86328,070 ± 1,08779,953 ± 5,883
PEGylated36.7 ± 3.0c1172 ± 8425,336 ± 1,11334,107 ± 1,03570,154 ± 2,008
  • Abbreviation: CTX, cabazitaxel.

  • aDetermined by MTT assay.

  • bStatistical analysis of IC50 values of SNM 1 or pSNM 1 as compared with that of free cabazitaxel.

  • cP < 0.001.

  • dP < 0.01.