Table 2.

Multivariate Cox proportional hazards model for OS

HR for death95% CI for HRSig.
A
 Adjuvant whole brain radiotherapy given0.080.01–0.510.008a
 Tumor size: longest axis > 30 mm2.800.85–9.250.091
 Low peritumoral FA (more white matter tract disruption)0.210.06–0.820.024a
B
 Adjuvant whole brain radiotherapy given0.100.03—0.390.001a
 Tumor size: longest axis > 30 mm3.371.29—8.810.013a
 High peritumoral density of CD3+ T cells0.400.13—1.250.114
C
 Low peritumoral FA (more white matter tract disruption)0.960.26–4.190.964
 High peritumoral density of CD3+ T cells0.080.12–0.490.007a
D
 Adjuvant whole brain radiotherapy given0.290.04–2.330.242
 Tumor size: longest axis > 30 mm3.110.87–11.180.082
 High peritumoral density of CD3+ T cells0.090.01–1.130.062
 Low peritumoral FA (more white matter tract disruption)0.830.11–6.580.862
  • NOTE: Models incorporating: A, All factors that were significant at univariate log-rank analysis. B, All factors significant at univariate analysis but with T-cell density substituted for peritumoral FA. C, Only FA and peritumoral T-cell infiltration, which confound one another. D, All factors significant at univariate analysis including both FA and peritumoral T-cell density.

  • aP < 0.05.