Table 2.

Multivariate Cox proportional hazards model for OS

	HR for death	95% CI for HR	Sig.
A
Adjuvant whole brain radiotherapy given	0.08	0.01–0.51	0.008^a
Tumor size: longest axis > 30 mm	2.80	0.85–9.25	0.091
Low peritumoral FA (more white matter tract disruption)	0.21	0.06–0.82	0.024^a
B
Adjuvant whole brain radiotherapy given	0.10	0.03—0.39	0.001^a
Tumor size: longest axis > 30 mm	3.37	1.29—8.81	0.013^a
High peritumoral density of CD3⁺ T cells	0.40	0.13—1.25	0.114
C
Low peritumoral FA (more white matter tract disruption)	0.96	0.26–4.19	0.964
High peritumoral density of CD3⁺ T cells	0.08	0.12–0.49	0.007^a
D
Adjuvant whole brain radiotherapy given	0.29	0.04–2.33	0.242
Tumor size: longest axis > 30 mm	3.11	0.87–11.18	0.082
High peritumoral density of CD3⁺ T cells	0.09	0.01–1.13	0.062
Low peritumoral FA (more white matter tract disruption)	0.83	0.11–6.58	0.862

NOTE: Models incorporating: A, All factors that were significant at univariate log-rank analysis. B, All factors significant at univariate analysis but with T-cell density substituted for peritumoral FA. C, Only FA and peritumoral T-cell infiltration, which confound one another. D, All factors significant at univariate analysis including both FA and peritumoral T-cell density.
↵^aP < 0.05.