Table 2.

Main features of common methods for the detection and study of CTC clusters

CellSearchMicrofluidic chipsFiltration devices
Robust clinical feasibilityX
Reduced processing time/ability to process whole bloodXX
Cell surface marker-independent isolation of CTC clustersX
Size-independent isolation of CTC clustersXX
Reduced risk of dissociation or omission of CTC clusters due density gradientXX
Ability to capture live CTC clustersX